CHKREC -| ATM ATR -> ATM DSB_ -> ATM FAcore -| ATM HRR2 -> CHKREC NHEJ -> CHKREC CHKREC -| CHKREC DSB_ -| CHKREC FAHRR -> CHKREC ICL -| CHKREC TLS -> CHKREC ADD -| CHKREC CHKREC -| p53 NHEJ -> p53 ATM -> p53 ATR -> p53 CHKREC -| ATR ATM -> ATR ICL -> ATR CHKREC -| HRR2 NHEJ -? HRR2 NUC2 -> HRR2 DSB_ -> HRR2 FAHRR -| HRR2 ICL -> HRR2 TLS -> HRR2 CHKREC -| FAcore ATM -> FAcore ATR -> FAcore ICL -> FAcore NHEJ -| FAHRR CHKREC -> FAHRR FANCD2I -> FAHRR DSB_ -> FAHRR NUC1 -> ADD NUC2 -> ADD TLS -| ADD HRR2 -| DSB_ NHEJ -| DSB_ NUC1 -> DSB_ FAHRR -| DSB_ NUC2 -> DSB_ CHKREC -| TLS ADD -> TLS FAcore -> TLS FANCD2I -> NUC1 ICL -> NUC1 DSB_ -| ICL ICL -> ICL p53 -> NUC2 FANCD2I -> NUC2 NUC1 -> NUC2 ATM -> NUC2 ATR -> NUC2 ICL -> NUC2 FAcore -| NUC2 CHKREC -| FANCD2I ATM -> FANCD2I ATR -> FANCD2I DSB_ -> FANCD2I FAcore -> FANCD2I HRR2 -| NHEJ CHKREC -| NHEJ FAHRR -| NHEJ NUC2 -> NHEJ DSB_ -> NHEJ $ADD: (((NUC1 & !TLS) | ((NUC1 & NUC2) & !TLS)) | (NUC2 & !TLS)) $ATM: ((ATR & !(CHKREC | FAcore)) | (DSB_ & !(CHKREC | FAcore))) $ATR: ((ICL & !CHKREC) | (ATM & !CHKREC)) $CHKREC: (((((TLS & !DSB_) | (FAHRR & !DSB_)) | (NHEJ & !DSB_)) | (HRR2 & !DSB_)) | !(((((((HRR2 | NHEJ) | CHKREC) | DSB_) | FAHRR) | ICL) | TLS) | ADD)) $DSB_: ((NUC2 & !((HRR2 | NHEJ) | FAHRR)) | (NUC1 & !((HRR2 | NHEJ) | FAHRR))) $FAHRR: ((FANCD2I & DSB_) & !(NHEJ & CHKREC)) $FANCD2I: ((FAcore & ((ATM | ATR) | (DSB_ & (ATM | ATR)))) & !CHKREC) $FAcore: ((ICL & (ATM | ATR)) & !CHKREC) $HRR2: (((TLS & (NUC2 & DSB_)) & !((FAHRR | CHKREC) | NHEJ)) | ((NUC2 & ((NHEJ & DSB_) & ICL)) & !(FAHRR | CHKREC))) $ICL: (ICL & !DSB_) $NHEJ: ((NUC2 & DSB_) & !((FAHRR | HRR2) | CHKREC)) $NUC1: (FANCD2I & ICL) $NUC2: (((NUC1 & (p53 & ICL)) & !(FAcore & FANCD2I)) | ((ICL & (ATM | ATR)) & !(FAcore & FANCD2I))) $TLS: ((ADD & !CHKREC) | ((FAcore & ADD) & !CHKREC)) $p53: (((ATM & !CHKREC) | (ATR & !CHKREC)) | (NHEJ & !CHKREC))